A diagnostic leader in personalized onco-medicine

Providing High-Quality Gene Expression Prognostic & Predictive Services for the Personalized Medicine
arena to Enable Better Management of Cancer Patients



Langenfeld, E., Deen, M., Zachariah, E.S., Langenfeld, J. Small molecule antagonist of the bone morphogenetic protein type I receptors suppresses growth and expression of Id1 and Id3 in lung cancer cells expressing Oct 4 or nestin. Mol. Cancer 12:129, 2013.

Kareddula, A., Zachariah, E.S., Notterman, D., Reiss, M. Type I receptor activity and ligand concentration are major determinants of transforming growth factor-ß- activated gene expression programs and cellular responses. J Epith. Biol. Phar. 1:40-53, 2008.

Tsafrir, D., Bacolod, M., Zachariah, E.S., Tsafrir, I., Shia, J., Zeng, Z., Liu, H., Krier, C., Stengel, R.F., Barany, F., Gerald, W.L., Paty, P.B., Domany, E., and Notterman, D.A. Relationship of gene expression and chromosomal abnormalities in colorectal cancer. Cancer Res 2006; 66:2129-2137.

Wen Y, Giardina SF, Hamming D, Greenman J, Zachariah E.S, Bacolod MD, Liu H, Shia J, Amenta PS, Barany F, Paty P, Gerald W, Notterman D. GROalpha is highly expressed in adenocarcinoma of the colon and down-regulates fibulin-1. Clin Cancer Res. 12:5951-5959, 2006.

Zachariah, E.S., Cheung, T.H., Wei, N., Vittal, R., Lo, K.W., Yeo, W., Kita, T., Ravatn, R., Chung, T.K., Wong, Y.F., and Chin, K.V. Prediction of chemotherapeutic response in ovarian cancer with DNA microarray expression profiling. Cancer Genet Cytogenet 2004; 154: 63-66.

Vittal, R., Zachariah, E.S., Hong, J., Yang, C.S., and Chin, K.V. Gene expression Changes Induced by Green tea Polyphenol (-)-Epigallocatechin-3-Gallate in Human bronchial epithelial 21 BES cells by DNA microarray. Mole Cancer Ther 2004; 3:1091-1099.

Liao, J.G., Lin, Y., Zachariah, E.S., and Shih, W.J. A mixture model for estimating the local false discovery rate in DNA microarray analysis. Bioinformatics 2004; 20:2694-2701.

Wong, Y.F., Zachariah, E.S.,* Wei, N., Porter, J., Vittal, R., Hu, R., Lin, Y., Liao, J., Shih, J.W., Cheung, T.K., Lo, K.W.K., Yim, S.F., Yip, S.K., Ngong, D.T., Siu, N.,  Chan, L.K.Y., Chan, C.S., Kong, T., Kutlina, E., McKinnon, R.D., Denhardt, D.T., Chin, K.V., and  Chung, T.K.H. Expression Genomics of Cervical Cancer: Molecular Classification and Prediction of Radiotherapy Response by DNA Microarray. Clin. Cancer Res 2003; 9: 5486-5492. *Contributed equally.

Rodriduez, I., Laure, M., Yan, T., Quanbo, Z., Chen, Y., Janak, S., Lim Tit, M., Sridhar, U., Hian K.L., Sam, F.Y.L., and  Zachariah, E.S.,*. Practical Integration of ploymerase chain reaction amplification and elecrophoretic analysis in microfuidic devices for genetic analysis. Electrophoresis 2003; 24:172-178. *Corresponding author.


Wu, Y.C., Zachariah, E.S.,* Wei, N., Peck, K., Whang-Peng, J., Hsu, W.H., Krier, C., and Notterman, D. Prediction of recurrence in non- small cell lung cancer by oligoarray gene expression profiling. Proc. Cancer Drugs: Research and Development, Philadelphia. 2005. pp 223-224. *Presenting author.

Invited Review Articles:

Chin, K.V., Alabanza, L., Fujii, K., Kudoh, K., Kita, T., Kikuchi, Y., Zachariah, E.S., Wong, Y.F., Lin, Y., and Shih, W.C. Application of expression genomics for predicting treatment response in cancer.  Ann N Y Acad Sci 2005; 1058:186-195.

Chin, K.V., Zachariah E.S., Vittal, R., Kita, T., Kudoh, K., Yang, C.S., Wong, Y.F., Cheung, T.K., Yeo, W., Chung, T.K.H., Lin, Y.,  Liao, J.,  Shih, J.W., Yap, S.F., and Lin. A.W. Application of Expression Genomics in Drug Development and Genomic Medicine. Drug Dev Res 2004; 62:124–133.

Book Chapter:

Book Title: Encyclopedia of Medical Devices and Instrumentation
Editor: John G. Webster
Chapter Title: Immunologically Sensitive Field-Effective Transistors.
Authors: Zachariah, E.S., Gopalakrishnakone. P., Neuzil, P.  
Publisher: John Wiley & Sons, Inc. Hoboken, NJ 07030. Year 2006; pp 98-110.